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SNCA variants are associated with increased risk for multiple system atrophy.


ABSTRACT: To test whether the synucleinopathies Parkinson's disease and multiple system atrophy (MSA) share a common genetic etiology, we performed a candidate single nucleotide polymorphism (SNP) association study of the 384 most associated SNPs in a genome-wide association study of Parkinson's disease in 413 MSA cases and 3,974 control subjects. The 10 most significant SNPs were then replicated in additional 108 MSA cases and 537 controls. SNPs at the SNCA locus were significantly associated with risk for increased risk for the development of MSA (combined p = 5.5 x 10(-12); odds ratio 6.2) [corrected].

SUBMITTER: Scholz SW 

PROVIDER: S-EPMC3520128 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature

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SNCA variants are associated with increased risk for multiple system atrophy.

Scholz Sonja W SW   Houlden Henry H   Schulte Claudia C   Sharma Manu M   Li Abi A   Berg Daniela D   Melchers Anna A   Paudel Reema R   Gibbs J Raphael JR   Simon-Sanchez Javier J   Paisan-Ruiz Coro C   Bras Jose J   Ding Jinhui J   Chen Honglei H   Traynor Bryan J BJ   Arepalli Sampath S   Zonozi Ryan R RR   Revesz Tamas T   Holton Janice J   Wood Nick N   Lees Andrew A   Oertel Wolfgang W   Wüllner Ullrich U   Goldwurm Stefano S   Pellecchia Maria Teresa MT   Illig Thomas T   Riess Olaf O   Fernandez Hubert H HH   Rodriguez Ramon L RL   Okun Michael S MS   Poewe Werner W   Wenning Gregor K GK   Hardy John A JA   Singleton Andrew B AB   Del Sorbo Francesca F   Schneider Susanne S   Bhatia Kailash P KP   Gasser Thomas T  

Annals of neurology 20090501 5


To test whether the synucleinopathies Parkinson's disease and multiple system atrophy (MSA) share a common genetic etiology, we performed a candidate single nucleotide polymorphism (SNP) association study of the 384 most associated SNPs in a genome-wide association study of Parkinson's disease in 413 MSA cases and 3,974 control subjects. The 10 most significant SNPs were then replicated in additional 108 MSA cases and 537 controls. SNPs at the SNCA locus were significantly associated with risk f  ...[more]

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