The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans.
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ABSTRACT:
SUBMITTER: Loftus BJ
PROVIDER: S-EPMC3520129 | biostudies-literature | 2005 Feb
REPOSITORIES: biostudies-literature
Publications
The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans.
Loftus Brendan J BJ Fung Eula E Roncaglia Paola P Rowley Don D Amedeo Paolo P Bruno Dan D Vamathevan Jessica J Miranda Molly M Anderson Iain J IJ Fraser James A JA Allen Jonathan E JE Bosdet Ian E IE Brent Michael R MR Chiu Readman R Doering Tamara L TL Donlin Maureen J MJ D'Souza Cletus A CA Fox Deborah S DS Grinberg Viktoriya V Fu Jianmin J Fukushima Marilyn M Haas Brian J BJ Huang James C JC Janbon Guilhem G Jones Steven J M SJ Koo Hean L HL Krzywinski Martin I MI Kwon-Chung June K JK Lengeler Klaus B KB Maiti Rama R Marra Marco A MA Marra Robert E RE Mathewson Carrie A CA Mitchell Thomas G TG Pertea Mihaela M Riggs Florenta R FR Salzberg Steven L SL Schein Jacqueline E JE Shvartsbeyn Alla A Shin Heesun H Shumway Martin M Specht Charles A CA Suh Bernard B BB Tenney Aaron A Utterback Terry R TR Wickes Brian L BL Wortman Jennifer R JR Wye Natasja H NH Kronstad James W JW Lodge Jennifer K JK Heitman Joseph J Davis Ronald W RW Fraser Claire M CM Hyman Richard W RW
Science (New York, N.Y.) 20050113 5713
Cryptococcus neoformans is a basidiomycetous yeast ubiquitous in the environment, a model for fungal pathogenesis, and an opportunistic human pathogen of global importance. We have sequenced its approximately 20-megabase genome, which contains approximately 6500 intron-rich gene structures and encodes a transcriptome abundant in alternatively spliced and antisense messages. The genome is rich in transposons, many of which cluster at candidate centromeric regions. The presence of these transposon ...[more]
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