Ontology highlight
ABSTRACT:
SUBMITTER: Rota R
PROVIDER: S-EPMC3520771 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
BMC medicine 20121116
Pediatric soft tissue sarcomas are rare tumors of childhood, frequently characterized by specific chromosome translocations. Despite improvements in treatment, their clinical management is often challenging due to the low responsiveness of metastatic forms and aggressive variants to conventional therapeutic approaches, which leads to poor overall survival. It is widely thought that soft tissue sarcomas derive from mesenchymal progenitor cells that, during embryonic life, have developed chromosom ...[more]