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Cellular immunotherapy for soft tissue sarcomas.


ABSTRACT: Soft tissue sarcomas are rare neoplasms, with approximately 9000 new cases in the USA every year. Unfortunately, during the past two decades, there has been little progress in the treatment of metastatic soft tissue sarcomas beyond the standard approaches of surgery, chemotherapy and radiation. Immunotherapy is a modality complementary to conventional therapy. It is appealing because functional antitumor activity could affect both local-regional and systemic disease, and act over a prolonged period of time. In this report, we review immunotherapeutic investigative strategies that are being developed, including several tumor vaccine, antigen vaccine and dendritic cell vaccine strategies.

SUBMITTER: Finkelstein SE 

PROVIDER: S-EPMC4501768 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature

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Cellular immunotherapy for soft tissue sarcomas.

Finkelstein Steven Eric SE   Fishman Mayer M   Conley Anthony P AP   Gabrilovich Dmitry D   Antonia Scott S   Chiappori Alberto A  

Immunotherapy 20120301 3


Soft tissue sarcomas are rare neoplasms, with approximately 9000 new cases in the USA every year. Unfortunately, during the past two decades, there has been little progress in the treatment of metastatic soft tissue sarcomas beyond the standard approaches of surgery, chemotherapy and radiation. Immunotherapy is a modality complementary to conventional therapy. It is appealing because functional antitumor activity could affect both local-regional and systemic disease, and act over a prolonged per  ...[more]

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