The crystal structure of human Argonaute2.
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ABSTRACT:
SUBMITTER: Schirle NT
PROVIDER: S-EPMC3521581 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Publications
The crystal structure of human Argonaute2.
Schirle Nicole T NT MacRae Ian J IJ
Science (New York, N.Y.) 20120426 6084
Argonaute proteins form the functional core of the RNA-induced silencing complexes that mediate RNA silencing in eukaryotes. The 2.3 angstrom resolution crystal structure of human Argonaute2 (Ago2) reveals a bilobed molecule with a central cleft for binding guide and target RNAs. Nucleotides 2 to 6 of a heterogeneous mixture of guide RNAs are positioned in an A-form conformation for base pairing with target messenger RNAs. Between nucleotides 6 and 7, there is a kink that may function in microRN ...[more]
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