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Crystal structure of human enterovirus 71.


ABSTRACT: Enterovirus 71 is a picornavirus associated with fatal neurological illness in infants and young children. Here, we report the crystal structure of enterovirus 71 and show that, unlike in other enteroviruses, the "pocket factor," a small molecule that stabilizes the virus, is partly exposed on the floor of the "canyon." Thus, the structure of antiviral compounds may require a hydrophilic head group designed to interact with residues at the entrance of the pocket.

SUBMITTER: Plevka P 

PROVIDER: S-EPMC3448362 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature

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Crystal structure of human enterovirus 71.

Plevka Pavel P   Perera Rushika R   Cardosa Jane J   Kuhn Richard J RJ   Rossmann Michael G MG  

Science (New York, N.Y.) 20120301 6086


Enterovirus 71 is a picornavirus associated with fatal neurological illness in infants and young children. Here, we report the crystal structure of enterovirus 71 and show that, unlike in other enteroviruses, the "pocket factor," a small molecule that stabilizes the virus, is partly exposed on the floor of the "canyon." Thus, the structure of antiviral compounds may require a hydrophilic head group designed to interact with residues at the entrance of the pocket. ...[more]

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