Ontology highlight
ABSTRACT:
SUBMITTER: Peters JM
PROVIDER: S-EPMC3521622 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Genes & development 20121201 23
Despite the prevalence of antisense transcripts in bacterial transcriptomes, little is known about how their synthesis is controlled. We report that a major function of the Escherichia coli termination factor Rho and its cofactor, NusG, is suppression of ubiquitous antisense transcription genome-wide. Rho binds C-rich unstructured nascent RNA (high C/G ratio) prior to its ATP-dependent dissociation of transcription complexes. NusG is required for efficient termination at minority subsets (~20%) ...[more]