Ontology highlight
ABSTRACT:
SUBMITTER: Peters TW
PROVIDER: S-EPMC3521677 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Peters Theodore W TW Rardin Matthew J MJ Czerwieniec Gregg G Evani Uday S US Reis-Rodrigues Pedro P Lithgow Gordon J GJ Mooney Sean D SD Gibson Bradford W BW Hughes Robert E RE
Molecular biology of the cell 20121024 24
Accumulation of insoluble protein in cells is associated with aging and aging-related diseases; however, the roles of insoluble protein in these processes are uncertain. The nature and impact of changes to protein solubility during normal aging are less well understood. Using quantitative mass spectrometry, we identify 480 proteins that become insoluble during postmitotic aging in Saccharomyces cerevisiae and show that this ensemble of insoluble proteins is similar to those that accumulate in ag ...[more]