Ontology highlight
ABSTRACT:
SUBMITTER: Jackson LP
PROVIDER: S-EPMC3521961 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Jackson Lauren P LP Lewis Michael M Kent Helen M HM Edeling Melissa A MA Evans Philip R PR Duden Rainer R Owen David J DJ
Developmental cell 20121121 6
COPI mediates retrograde trafficking from the Golgi to the endoplasmic reticulum (ER) and within the Golgi stack, sorting transmembrane proteins bearing C-terminal KKxx or KxKxx motifs. The structure of KxKxx motifs bound to the N-terminal WD-repeat domain of β'-COP identifies electrostatic contacts between the motif and complementary patches at the center of the β'-COP propeller. An absolute requirement of a two-residue spacing between the terminal carboxylate group and first lysine residue res ...[more]