Ontology highlight
ABSTRACT:
SUBMITTER: Leemhuis J
PROVIDER: S-EPMC3523719 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Leemhuis Jost J Bouché Elisabeth E Frotscher Michael M Henle Frank F Hein Lutz L Herz Joachim J Meyer Dieter K DK Pichler Marina M Roth Günter G Schwan Carsten C Bock Hans H HH
The Journal of neuroscience : the official journal of the Society for Neuroscience 20101101 44
Lipoprotein receptor signaling regulates the positioning and differentiation of postmitotic neurons during development and modulates neuronal plasticity in the mature brain. Depending on the contextual situation, the lipoprotein receptor ligand Reelin can have opposing effects on cortical neurons. We show that Reelin increases growth cone motility and filopodia formation, and identify the underlying signaling cascade. Reelin activates the Rho GTPase Cdc42, known for its role in neuronal morphoge ...[more]