Ontology highlight
ABSTRACT:
SUBMITTER: Kayser MS
PROVIDER: S-EPMC2617787 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
Kayser Matthew S MS Nolt Mark J MJ Dalva Matthew B MB
Neuron 20080701 1
Motile dendritic filopodial processes are thought to be precursors of spine synapses, but how motility relates to cell-surface cues required for axon-dendrite recognition and synaptogenesis remains unclear. We demonstrate with dynamic imaging that loss of EphBs results in reduced motility of filopodia in cultured cortical neurons and brain slice. EphB knockdown and rescue experiments during different developmental time windows show that EphBs are required for synaptogenesis only when filopodia a ...[more]