Ontology highlight
ABSTRACT:
SUBMITTER: Tsuji Y
PROVIDER: S-EPMC3523885 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Tsuji Yoshihisa Y Watanabe Tomohiro T Kudo Masatoshi M Arai Hidenori H Strober Warren W Chiba Tsutomu T
Immunity 20120816 2
The intracellular sensor NOD1 has important host-defense functions relating to a variety of pathogens. Here, we showed that this molecule also participates in the induction of a noninfectious pancreatitis via its response to commensal organisms. Pancreatitis induced by high-dose cerulein (a cholecystokinin receptor agonist) administration depends on NOD1 stimulation by gut microflora. To analyze this NOD1 activity, we induced pancreatitis by simultaneous administration of a low dose of cerulein ...[more]