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Caspase-11, a specific sensor for intracellular lipopolysaccharide recognition, mediates the non-canonical inflammatory pathway of pyroptosis.


ABSTRACT: Pyroptosis, a type of programmed cell death that along with inflammation, is mainly regulated by two main pathways, cysteinyl aspartate specific proteinase (caspase)-1-induced canonical inflammatory pathway and caspase-11-induced non-canonical inflammatory pathway. The non-canonical inflammatory pathway-induced pyroptosis is a unique immune response in response to gram-negative (G-) bacteria. It is induced by lipopolysaccharide (LPS) on the surface of G- bacteria. This activates caspase-11 which, in turn, activates a series of downstream proteins eventually forming protein pores on the cell membrane and inducing cell sacrificial processes. Caspase-11 belongs to the caspase family and is an homologous protein of caspase-1. It has the ability to specifically hydrolyze proteins, but it is still unclear how it regulates cell death caused by non-canonical inflammatory pathways. The present study describes a pathway that enables LPS to directly enter the cell and activate caspase-11, and the key role caspase-11 plays in the activation of pyroptosis and inflammation.

SUBMITTER: Huang X 

PROVIDER: S-EPMC6438033 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Caspase-11, a specific sensor for intracellular lipopolysaccharide recognition, mediates the non-canonical inflammatory pathway of pyroptosis.

Huang Xiaoli X   Feng Yang Y   Xiong Guanqing G   Whyte Shona S   Duan Jing J   Yang Yucen Y   Wang Kaiyu K   Yang Shiyong S   Geng Yi Y   Ou Yangping Y   Chen Defang D  

Cell & bioscience 20190327


Pyroptosis, a type of programmed cell death that along with inflammation, is mainly regulated by two main pathways, cysteinyl aspartate specific proteinase (caspase)-1-induced canonical inflammatory pathway and caspase-11-induced non-canonical inflammatory pathway. The non-canonical inflammatory pathway-induced pyroptosis is a unique immune response in response to gram-negative (G<sup>-</sup>) bacteria. It is induced by lipopolysaccharide (LPS) on the surface of G<sup>-</sup> bacteria. This acti  ...[more]

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