Ontology highlight
ABSTRACT:
SUBMITTER: Wang J
PROVIDER: S-EPMC3525523 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Wang Jianbin J Fan H Christina HC Behr Barry B Quake Stephen R SR
Cell 20120701 2
Meiotic recombination and de novo mutation are the two main contributions toward gamete genome diversity, and many questions remain about how an individual human's genome is edited by these two processes. Here, we describe a high-throughput method for single-cell whole-genome analysis that was used to measure the genomic diversity in one individual's gamete genomes. A microfluidic system was used for highly parallel sample processing and to minimize nonspecific amplification. High-density genoty ...[more]