Ontology highlight
ABSTRACT:
SUBMITTER: Lee IY
PROVIDER: S-EPMC3525752 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Lee Ill-Young IY Gruber Todd D TD Samuels Amanda A Yun Minhan M Nam Bora B Kang Minseo M Crowley Kathryn K Winterroth Benjamin B Boshoff Helena I HI Barry Clifton E CE
Bioorganic & medicinal chemistry 20121115 1
A series of salicylanilides was synthesized based on a high-throughput screening hit against Mycobacterium tuberculosis. A free phenolic hydroxyl on the salicylic acid moeity is required for activity, and the structure-activity relationship of the aniline ring is largely driven by the presence of electron withdrawing groups. We synthesized 94 analogs exploring substitutions of both rings and the linker region in this series and we have identified multiple compounds with low micromolar potency. U ...[more]