Ontology highlight
ABSTRACT:
SUBMITTER: Ling J
PROVIDER: S-EPMC3525788 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Ling Jiqiang J Cho Chris C Guo Li-Tao LT Aerni Hans R HR Rinehart Jesse J Söll Dieter D
Molecular cell 20121030 5
Protein mistranslation causes growth arrest in bacteria, mitochondrial dysfunction in yeast, and neurodegeneration in mammals. It remains poorly understood how mistranslated proteins cause such cellular defects. Here we demonstrate that streptomycin, a bactericidal aminoglycoside that increases ribosomal mistranslation, induces transient protein aggregation in wild-type Escherichia coli. We further determined the aggregated proteome using label-free quantitative mass spectrometry. To identify ge ...[more]