Ontology highlight
ABSTRACT:
SUBMITTER: Rollinger JM
PROVIDER: S-EPMC3526713 | biostudies-literature | 2006 Sep
REPOSITORIES: biostudies-literature
Rollinger Judith M JM Schuster Daniela D Baier Elisabeth E Ellmerer Ernst P EP Langer Thierry T Stuppner Hermann H
Journal of natural products 20060901 9
A bioactivity-guided approach was taken to identify the acetylcholinesterase (AChE, EC 3.1.1.7) inhibitory agent in a Magnolia x soulangiana extract using a microplate enzyme assay with Ellman's reagent. This permitted the isolation of the alkaloids taspine (1) and (-)-asimilobine (2), which were detected for the first time in this species. Compound 1 showed a significantly higher effect on AChE than the positive control galanthamine and selectively inhibited the enzyme in a long-lasting and con ...[more]