Dataset Information

Bioactivity-Guided Isolation of Antimicrobial and Antioxidant Metabolites from the Mushroom Tapinella atrotomentosa.

ABSTRACT: Bioassay-guided fractionation of the chloroform extract of Tapinella atrotomentosa led to the isolation of four secondary metabolites 1?4. Two of the compounds are lactones—osmundalactone (1) and 5-hydroxy-hex-2-en-4-olide (2)—while 3 and 4 were identified as terphenyl quinones, spiromentins C and B, respectively. The structures of the compounds were established on the basis of NMR and MS spectroscopic analysis. The isolated fungal metabolites were evaluated for their antibacterial activities against several Gram-positive and negative bacteria. In addition, their synergistic effect with cefuroxime against methicillin-resistant Staphylococcus aureus (MRSA) was also evaluated. Compounds 1?3 proved to possess significant antibacterial activity against multiresistant Acinetobacter baumannii and extended-spectrum ?-lactamase (ESBL)-producing Escherichia coli. The investigation of the antioxidant effect of the isolated compounds in DPPH and ORAC assays revealed that spiromentins C (3) and B (4) have remarkable antioxidant activity.

SUBMITTER: Beni Z

PROVIDER: S-EPMC6102582 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature

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Bioactivity-Guided Isolation of Antimicrobial and Antioxidant Metabolites from the Mushroom Tapinella atrotomentosa.

Béni Zoltán Z Dékány Miklós M Kovács Bernadett B Csupor-Löffler Boglárka B Zomborszki Zoltán Péter ZP Kerekes Erika E Szekeres András A Urbán Edit E Hohmann Judit J Ványolós Attila A

Molecules (Basel, Switzerland) 20180504 5

Bioassay-guided fractionation of the chloroform extract of Tapinella atrotomentosa led to the isolation of four secondary metabolites 1⁻4. Two of the compounds are lactones—osmundalactone (1) and 5-hydroxy-hex-2-en-4-olide (2)—while 3 and 4 were identified as terphenyl quinones, spiromentins C and B, respectively. The structures of the compounds were established on the basis of NMR and MS spectroscopic analysis. The isolated fungal metabolites wer ...[more]

PMID: 29734648

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Dataset Information

Bioactivity-Guided Isolation of Antimicrobial and Antioxidant Metabolites from the Mushroom Tapinella atrotomentosa.

Publications

Bioactivity-Guided Isolation of Antimicrobial and Antioxidant Metabolites from the Mushroom <i>Tapinella atrotomentosa</i>.

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