Ontology highlight
ABSTRACT:
SUBMITTER: Heissler SM
PROVIDER: S-EPMC3527664 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
FEBS letters 20120731 19
Myosin-6 is an actin-based motor protein that moves its cargo towards the minus-end of actin filaments. Mutations in the gene encoding the myosin-6 heavy chain and changes in the cellular abundance of the protein have been linked to hypertrophic cardiomyopathy, neurodegenerative diseases, and cancer. Here, we present a detailed kinetic characterization of the human myosin-6 motor domain, describe the effect of 2,4,6-triiodophenol on the interaction of myosin-6 with F-actin and nucleotides, and s ...[more]