Ontology highlight
ABSTRACT:
SUBMITTER: Levi B
PROVIDER: S-EPMC3528603 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Levi Benjamin B Hyun Jeong S JS Montoro Daniel T DT Lo David D DD Chan Charles K F CK Hu Shijun S Sun Ning N Lee Min M Grova Monica M Connolly Andrew J AJ Wu Joseph C JC Gurtner Geoffrey C GC Weissman Irving L IL Wan Derrick C DC Longaker Michael T MT
Proceedings of the National Academy of Sciences of the United States of America 20121120 50
Pluripotent cells represent a powerful tool for tissue regeneration, but their clinical utility is limited by their propensity to form teratomas. Little is known about their interaction with the surrounding niche following implantation and how this may be applied to promote survival and functional engraftment. In this study, we evaluated the ability of an osteogenic microniche consisting of a hydroxyapatite-coated, bone morphogenetic protein-2-releasing poly-L-lactic acid scaffold placed within ...[more]