Ontology highlight
ABSTRACT:
SUBMITTER: Qian T
PROVIDER: S-EPMC5677350 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Qian Tongcheng T Maguire Shaenah E SE Canfield Scott G SG Bao Xiaoping X Olson William R WR Shusta Eric V EV Palecek Sean P SP
Science advances 20171108 11
The blood-brain barrier (BBB) is composed of specialized endothelial cells that are critical to neurological health. A key tool for understanding human BBB development and its role in neurological disease is a reliable and scalable source of functional brain microvascular endothelial cells (BMECs). Human pluripotent stem cells (hPSCs) can theoretically generate unlimited quantities of any cell lineage in vitro, including BMECs, for disease modeling, drug screening, and cell-based therapies. We d ...[more]