Ontology highlight
ABSTRACT:
SUBMITTER: Kasmapour B
PROVIDER: S-EPMC3528610 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Kasmapour Bahram B Gronow Achim A Bleck Christopher K E CK Hong Wanjin W Gutierrez Maximiliano Gabriel MG
Proceedings of the National Academy of Sciences of the United States of America 20121128 50
Phagosome maturation is an essential part of the innate and adaptive immune response. Although it is well established that several Ras-related proteins in brain (Rab) proteins become associated to phagosomes, little is known about how these phagosomal Rab proteins influence phagosome maturation. Here, we show a specific role for Rab34 and mammalian uncoordinated 13-2 (Munc13-2) in phagolysosome biogenesis and cargo delivery. Rab34 knockdown impaired the fusion of phagosomes with late endosomes/l ...[more]