Anti-amyloid-?-mediated positron emission tomography imaging in Alzheimer's disease mouse brains.
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ABSTRACT:
SUBMITTER: McLean D
PROVIDER: S-EPMC3528731 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Publications
Anti-amyloid-β-mediated positron emission tomography imaging in Alzheimer's disease mouse brains.
McLean Daniel D Cooke Michael J MJ Wang Yuanfei Y Green David D Fraser Paul E PE George-Hyslop Peter St PS Shoichet Molly S MS
PloS one 20121221 12
Antibody-mediated imaging of amyloid β (Aβ) in Alzheimer's disease (AD) offers a promising strategy to detect and monitor specific Aβ species, such as oligomers, that have important pathological and therapeutic relevance. The major current limitation of antibodies as a diagnostic and imaging device is poor blood-brain-barrier permeability. A classical anti-Aβ antibody, 6E10, is modified with 10 kDa polyethylene glycol (PEG) and a positron emitting isotope, Copper-64 (t(½) = 12.7 h), and intraven ...[more]
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