Ontology highlight
ABSTRACT:
SUBMITTER: Li W
PROVIDER: S-EPMC3529047 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Li Wendong W Tian E E Chen Zhao-Xia ZX Sun Guoqiang G Ye Peng P Yang Su S Lu Dave D Xie Jun J Ho Thach-Vu TV Tsark Walter M WM Wang Charles C Horne David A DA Riggs Arthur D AD Yip M L Richard ML Shi Yanhong Y
Proceedings of the National Academy of Sciences of the United States of America 20121203 51
One of the hurdles for practical application of induced pluripotent stem cells (iPSC) is the low efficiency and slow process of reprogramming. Octamer-binding transcription factor 4 (Oct4) has been shown to be an essential regulator of embryonic stem cell (ESC) pluripotency and key to the reprogramming process. To identify small molecules that enhance reprogramming efficiency, we performed a cell-based high-throughput screening of chemical libraries. One of the compounds, termed Oct4-activating ...[more]