Ontology highlight
ABSTRACT:
SUBMITTER: Wang J
PROVIDER: S-EPMC4303016 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Wang Ji J Huang Vera V Ye Lin L Bárcena Alicia A Lin Guiting G Lue Tom F TF Li Long-Cheng LC
Stem cells and development 20141103 3
Ectopic overexpression of transcription factors has been used to reprogram cell fate. For example, virus-mediated overexpression of four transcription factors OCT4, SOX2, MYC, and KLF4, known as Yamanaka factors, can convert somatic cells to induced pluripotent stem (iPS) cells. However, gene-specific switch-on of endogenous gene production without the use of foreign DNA remains a challenge. The small RNA machinery that comprised small RNAs and Argonaute proteins is known to silence gene express ...[more]