Ontology highlight
ABSTRACT:
SUBMITTER: Cochella L
PROVIDER: S-EPMC3529140 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Cochella Luisa L Hobert Oliver O
Cell 20121129 6
The mechanisms by which functional left/right asymmetry arises in morphologically symmetric nervous systems are poorly understood. Here, we provide a mechanistic framework for how functional asymmetry in a postmitotic neuron pair is specified in C. elegans. A key feature of this mechanism is a temporally separated, two-step activation of the lsy-6 miRNA locus. The lsy-6 locus is first "primed" by chromatin decompaction in the precursor for the left neuron, but not the right neuron, several divis ...[more]