Ontology highlight
ABSTRACT:
SUBMITTER: Schmidt KN
PROVIDER: S-EPMC3529528 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
The Journal of cell biology 20121217 7
Cilia formation is a multi-step process that starts with the docking of a vesicle at the distal part of the mother centriole. This step marks the conversion of the mother centriole into the basal body, from which axonemal microtubules extend to form the ciliary compartment. How vesicles are stably attached to the mother centriole to initiate ciliary membrane biogenesis is unknown. Here, we investigate the molecular role of the mother centriolar component Cep164 in ciliogenesis. We show that Cep1 ...[more]