Ontology highlight
ABSTRACT:
SUBMITTER: Huang N
PROVIDER: S-EPMC6207757 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Huang Ning N Zhang Donghui D Li Fangyuan F Chai Peiyuan P Wang Song S Teng Junlin J Chen Jianguo J
Nature communications 20181030 1
The primary cilium is elongated from the mother centriole and has diverse signaling roles during development and disease. The CP110-CEP97 complex functions as a negative regulator of ciliogenesis, although the mechanisms regulating its mother centriole localization are poorly understood. Here we show that M-Phase Phosphoprotein 9 (MPP9) is recruited by Kinesin Family Member 24 (KIF24) to the distal end of mother centriole where it forms a ring-like structure and recruits CP110-CEP97 by directly ...[more]