Ontology highlight
ABSTRACT:
SUBMITTER: Naito AT
PROVIDER: S-EPMC3529917 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Cell 20120601 6
Wnt signaling plays critical roles in development of various organs and pathogenesis of many diseases, and augmented Wnt signaling has recently been implicated in mammalian aging and aging-related phenotypes. We here report that complement C1q activates canonical Wnt signaling and promotes aging-associated decline in tissue regeneration. Serum C1q concentration is increased with aging, and Wnt signaling activity is augmented during aging in the serum and in multiple tissues of wild-type mice, bu ...[more]