Ontology highlight
ABSTRACT:
SUBMITTER: Nalapareddy K
PROVIDER: S-EPMC5987258 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Nalapareddy Kodandaramireddy K Nattamai Kalpana J KJ Kumar Rupali S RS Karns Rebekah R Wikenheiser-Brokamp Kathryn A KA Sampson Leesa L LL Mahe Maxime M MM Sundaram Nambirajan N Yacyshyn Mary-Beth MB Yacyshyn Bruce B Helmrath Michael A MA Zheng Yi Y Geiger Hartmut H
Cell reports 20170301 11
Although intestinal homeostasis is maintained by intestinal stem cells (ISCs), regeneration is impaired upon aging. Here, we first uncover changes in intestinal architecture, cell number, and cell composition upon aging. Second, we identify a decline in the regenerative capacity of ISCs upon aging because of a decline in canonical Wnt signaling in ISCs. Changes in expression of Wnts are found in stem cells themselves and in their niche, including Paneth cells and mesenchyme. Third, reactivating ...[more]