Ontology highlight
ABSTRACT:
SUBMITTER: Estevez-Garcia P
PROVIDER: S-EPMC3531259 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Estevez-Garcia Purificacion P Castaño Angel A Martin Ana C AC Lopez-Rios Fernando F Iglesias Joaquin J Muñoz-Galván Sandra S Lopez-Calderero Iker I Molina-Pinelo Sonia S Pastor Maria D MD Carnero Amancio A Paz-Ares Luis L Garcia-Carbonero Rocio R
BMC cancer 20121112
<h4>Background</h4>Angiogenesis plays an essential role in tumor growth and metastasis, and is a major target in cancer therapy. VEGFR and PDGFR are key players involved in this process. The purpose of this study was to assess the incidence of genetic variants in these receptors and its potential clinical implications in colorectal cancer (CRC).<h4>Methods</h4>VEGFR2, PDGFRα and PDGFRβ mutations were evaluated by sequencing their tyrosine kinase domains in 8 CRC cell lines and in 92 samples of p ...[more]