Ontology highlight
ABSTRACT:
SUBMITTER: O'Keeffe GW
PROVIDER: S-EPMC3531920 | biostudies-literature | 2008 Feb
REPOSITORIES: biostudies-literature
O'Keeffe Gerard W GW Gutierrez Humberto H Pandolfi Pier Paolo PP Riccardi Carlo C Davies Alun M AM
Nature neuroscience 20080106 2
Nerve growth factor (NGF) has an important role in regulating sympathetic neuron survival and target field innervation during development. Here we show that glucocorticoid-induced tumor necrosis factor receptor-related protein (GITR), a member of the TNF superfamily, and its ligand (GITRL) are co-expressed in mouse sympathetic neurons when their axons are innervating their targets under the influence of target-derived NGF. In culture, GITRL enhanced NGF-promoted neurite growth from neonatal symp ...[more]