Ontology highlight
ABSTRACT:
SUBMITTER: Howard L
PROVIDER: S-EPMC6262789 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Development (Cambridge, England) 20181119 22
TWE-PRIL is a naturally occurring fusion protein of components of two TNF superfamily members: the extracellular domain of APRIL; and the intracellular and transmembrane domains of TWEAK with no known function. Here, we show that <i>April</i><sup>-/-</sup> mice (which lack APRIL and TWE-PRIL) exhibited overgrowth of sympathetic fibres <i>in vivo</i>, and sympathetic neurons cultured from these mice had significantly longer axons than neurons cultured from wild-type littermates. Enhanced axon gro ...[more]