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A possible genetic link between MTHFR genotype and smoking behavior.

ABSTRACT: BACKGROUND: Hyperhomocysteinemia is an independent risk factor for stroke and other vascular events. The variant methylenetetrahydrofolate reductase (MTHFR) C677T is associated with elevated homocysteine levels, cardiovascular disease and stroke, which supports a causal relationship between hyperhomocysteinemia and vascular disease. However, MTHFR variants have also been reported to be associated with smoking behavior, which could be an important confounder. METHODOLOGY/PRINCIPAL FINDINGS: We analyzed the MTHFR variants C677T and A1298C in two independent samples of 525 and 535 individuals, respectively. 21% of the non-smokers, but only 12% of the smokers were homozygous carriers of both MTHFR wildtype alleles, i.e. 677CC and 1298AA (Chi²?=?15.8; p<0.001; binary regression). Plasma homocysteine levels were higher in smokers (13.9±4.1 µmol/L) than in non-smokers (12.6±4.0 µmol/L; F?=?11.4; p?=?0.001; ANOVA). Smoking MTHFR 677TT individuals had the highest plasma homocysteine levels (16.2±5.2 µmol/L), non-smoking 677CC individuals had the lowest (12.2±13.6 µmol/L). CONCLUSIONS/SIGNIFICANCE: In our study samples, MTHFR variants and smoking behaviour were associated with homocysteine plasma levels. In addition, the MTHFR variants were associated with smoking behaviour. Such an association may be a relevant confounder between MTHFR variants, homocysteine plasma levels and vascular diseases.

SUBMITTER: Linnebank M

PROVIDER: S-EPMC3532068 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature

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A possible genetic link between MTHFR genotype and smoking behavior.

Linnebank Michael M Moskau Susanna S Semmler Alexander A Hoefgen Barbara B Bopp Gisela G Kallweit Ulf U Maier Wolfgang W Schütz Christian G CG Wüllner Ullrich U

PloS one 20121228 12

<h4>Background</h4>Hyperhomocysteinemia is an independent risk factor for stroke and other vascular events. The variant methylenetetrahydrofolate reductase (MTHFR) C677T is associated with elevated homocysteine levels, cardiovascular disease and stroke, which supports a causal relationship between hyperhomocysteinemia and vascular disease. However, MTHFR variants have also been reported to be associated with smoking behavior, which could be an important confounder.<h4>Methodology/principal findi ...[more]

PMID: 23285280

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A possible genetic link between MTHFR genotype and smoking behavior.

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A possible genetic link between MTHFR genotype and smoking behavior.

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