Ontology highlight
ABSTRACT:
SUBMITTER: Kucuk C
PROVIDER: S-EPMC3532710 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Küçük Can C Hu Xiaozhou X Iqbal Javeed J Gaulard Philippe P Klinkebiel David D Cornish Adam A Dave Bhavana J BJ Chan Wing C WC
The American journal of pathology 20121109 1
HACE1 is an E3 ubiquitin ligase located in 6q21, the genomic region frequently deleted in natural killer (NK) cell malignancies. Here, we report HACE1 as a candidate tumor suppressor gene silenced through a combination of deletion and cytosine phosphate guanine island hypermethylation. We detected deletion of HACE1 in malignant NK cell lines (6 of 9, 67%) and primary biopsies (5 of 15, 33%) by quantitative PCR, with most of the specimen showing cytosine phosphate guanine island hypermethylation ...[more]