Dataset Information

A fine-scale chimpanzee genetic map from population sequencing.

ABSTRACT: To study the evolution of recombination rates in apes, we developed methodology to construct a fine-scale genetic map from high-throughput sequence data from 10 Western chimpanzees, Pan troglodytes verus. Compared to the human genetic map, broad-scale recombination rates tend to be conserved, but with exceptions, particularly in regions of chromosomal rearrangements and around the site of ancestral fusion in human chromosome 2. At fine scales, chimpanzee recombination is dominated by hotspots, which show no overlap with those of humans even though rates are similarly elevated around CpG islands and decreased within genes. The hotspot-specifying protein PRDM9 shows extensive variation among Western chimpanzees, and there is little evidence that any sequence motifs are enriched in hotspots. The contrasting locations of hotspots provide a natural experiment, which demonstrates the impact of recombination on base composition.

SUBMITTER: Auton A

PROVIDER: S-EPMC3532813 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature

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A fine-scale chimpanzee genetic map from population sequencing.

Auton Adam A Fledel-Alon Adi A Pfeifer Susanne S Venn Oliver O Ségurel Laure L Street Teresa T Leffler Ellen M EM Bowden Rory R Aneas Ivy I Broxholme John J Humburg Peter P Iqbal Zamin Z Lunter Gerton G Maller Julian J Hernandez Ryan D RD Melton Cord C Venkat Aarti A Nobrega Marcelo A MA Bontrop Ronald R Myers Simon S Donnelly Peter P Przeworski Molly M McVean Gil G

Science (New York, N.Y.) 20120315 6078

To study the evolution of recombination rates in apes, we developed methodology to construct a fine-scale genetic map from high-throughput sequence data from 10 Western chimpanzees, Pan troglodytes verus. Compared to the human genetic map, broad-scale recombination rates tend to be conserved, but with exceptions, particularly in regions of chromosomal rearrangements and around the site of ancestral fusion in human chromosome 2. At fine scales, chimpanzee recombination is dominated by hotspots, w ...[more]

PMID: 22422862

Dataset Information

A fine-scale chimpanzee genetic map from population sequencing.

Publications

A fine-scale chimpanzee genetic map from population sequencing.

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