Ontology highlight
ABSTRACT:
SUBMITTER: Muller TD
PROVIDER: S-EPMC3533288 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
The Journal of clinical investigation 20121221 1
The scaffold protein p62 (sequestosome 1; SQSTM1) is an emerging key molecular link among the metabolic, immune, and proliferative processes of the cell. Here, we report that adipocyte-specific, but not CNS-, liver-, muscle-, or myeloid-specific p62-deficient mice are obese and exhibit a decreased metabolic rate caused by impaired nonshivering thermogenesis. Our results show that p62 regulates energy metabolism via control of mitochondrial function in brown adipose tissue (BAT). Accordingly, adi ...[more]