Ontology highlight
ABSTRACT:
SUBMITTER: Fischer K
PROVIDER: S-EPMC7211001 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Nature communications 20200508 1
During β-adrenergic stimulation of brown adipose tissue (BAT), p38 phosphorylates the activating transcription factor 2 (ATF2) which then translocates to the nucleus to activate the expression of Ucp1 and Pgc-1α. The mechanisms underlying ATF2 target activation are unknown. Here we demonstrate that p62 (Sqstm1) binds to ATF2 to orchestrate activation of the Ucp1 enhancer and Pgc-1α promoter. P62<sup>Δ69-251</sup> mice show reduced expression of Ucp1 and Pgc-1α with impaired ATF2 genomic binding. ...[more]