Ontology highlight
ABSTRACT:
SUBMITTER: Serohijos AW
PROVIDER: S-EPMC3533372 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Serohijos Adrian W R AW Rimas Zilvinas Z Shakhnovich Eugene I EI
Cell reports 20120802 2
The consistent observation across all kingdoms of life that highly abundant proteins evolve slowly demonstrates that cellular abundance is a key determinant of protein evolutionary rate. However, other empirical findings, such as the broad distribution of evolutionary rates, suggest that additional variables determine the rate of protein evolution. Here, we report that under the global selection against the cytotoxic effects of misfolded proteins, folding stability (ΔG), simultaneous with abunda ...[more]