Ontology highlight
ABSTRACT:
SUBMITTER: Yang JR
PROVIDER: S-EPMC3325723 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Yang Jian-Rong JR Liao Ben-Yang BY Zhuang Shi-Mei SM Zhang Jianzhi J
Proceedings of the National Academy of Sciences of the United States of America 20120313 14
The tempo and mode of protein evolution have been central questions in biology. Genomic data have shown a strong influence of the expression level of a protein on its rate of sequence evolution (E-R anticorrelation), which is currently explained by the protein misfolding avoidance hypothesis. Here, we show that this hypothesis does not fully explain the E-R anticorrelation, especially for protein surface residues. We propose that natural selection against protein-protein misinteraction, which wa ...[more]