Ontology highlight
ABSTRACT:
SUBMITTER: Tang W
PROVIDER: S-EPMC3534863 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Tang Wei W Dominska Margaret M Gawel Malgorzata M Greenwell Patricia W PW Petes Thomas D TD
DNA repair 20121120 1
Expansion of certain trinucleotide repeats causes several types of human diseases, and such tracts are associated with the formation of deletions and other types of genetic rearrangements in Escherichia coli, yeast, and mammalian cells. Below, we show that long (230 repeats) tracts of the trinucleotide associated with Friedreich's ataxia (GAA·TTC) stimulate both large (>50 bp) deletions and point mutations in a reporter gene located more than 1 kb from the repetitive tract. Sequence analysis of ...[more]