Ontology highlight
ABSTRACT:
SUBMITTER: Helma R
PROVIDER: S-EPMC6600395 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Helma Robert R Bažantová Pavla P Petr Marek M Adámik Matej M Renčiuk Daniel D Tichý Vlastimil V Pastuchová Alena A Soldánová Zuzana Z Pečinka Petr P Bowater Richard P RP Fojta Miroslav M Brázdová Marie M
Molecules (Basel, Switzerland) 20190531 11
Expansions of trinucleotide repeats (TNRs) are associated with genetic disorders such as Friedreich's ataxia. The tumor suppressor p53 is a central regulator of cell fate in response to different types of insults. Sequence and structure-selective modes of DNA recognition are among the main attributes of p53 protein. The focus of this work was analysis of the p53 structure-selective recognition of TNRs associated with human neurodegenerative diseases. Here, we studied binding of full length p53 a ...[more]