Phosphofructokinase 1 glycosylation regulates cell growth and metabolism.
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ABSTRACT:
SUBMITTER: Yi W
PROVIDER: S-EPMC3534962 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Publications
Phosphofructokinase 1 glycosylation regulates cell growth and metabolism.
Yi Wen W Clark Peter M PM Mason Daniel E DE Keenan Marie C MC Hill Collin C Goddard William A WA Peters Eric C EC Driggers Edward M EM Hsieh-Wilson Linda C LC
Science (New York, N.Y.) 20120801 6097
Cancer cells must satisfy the metabolic demands of rapid cell growth within a continually changing microenvironment. We demonstrated that the dynamic posttranslational modification of proteins by O-linked β-N-acetylglucosamine (O-GlcNAcylation) is a key metabolic regulator of glucose metabolism. O-GlcNAcylation was induced at serine 529 of phosphofructokinase 1 (PFK1) in response to hypoxia. Glycosylation inhibited PFK1 activity and redirected glucose flux through the pentose phosphate pathway, ...[more]
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