Ontology highlight
ABSTRACT:
SUBMITTER: Caradonna KL
PROVIDER: S-EPMC3560928 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Caradonna Kacey L KL Engel Juan C JC Jacobi David D Lee Chih-Hao CH Burleigh Barbara A BA
Cell host & microbe 20130116 1
Metabolic coupling of intracellular pathogens with host cells is essential for successful colonization of the host. Establishment of intracellular infection by the protozoan Trypanosoma cruzi leads to the development of human Chagas' disease, yet the functional contributions of the host cell toward the infection process remain poorly characterized. Here, a genome-scale functional screen identified interconnected metabolic networks centered around host energy production, nucleotide metabolism, pt ...[more]