Ontology highlight
ABSTRACT:
SUBMITTER: Krishnamoorthy J
PROVIDER: S-EPMC3535185 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Krishnamoorthy Janarthanan J Brender Jeffrey R JR Vivekanandan Subramanian S Jahr Nicole N Ramamoorthy Ayyalusamy A
The journal of physical chemistry. B 20121112 46
Low-lying excited states that correspond to rare conformations or transiently bound species have been hypothesized to play an important role for amyloid nucleation. Despite their hypothesized importance in amyloid formation, transiently occupied states have proved difficult to detect directly. To experimentally characterize these invisible states, we performed a series of Carr-Purcell-Meiboom-Gill (CPMG)-based relaxation dispersion NMR experiments for the amyloidogenic Aβ(1-40) peptide implicate ...[more]