Ontology highlight
ABSTRACT:
SUBMITTER: Liu M
PROVIDER: S-EPMC3535262 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Liu Mei M Choi Dong-Young DY Hunter Randy L RL Pandya Jignesh D JD Cass Wayne A WA Sullivan Patrick G PG Kim Hyoung-Chun HC Gash Don M DM Bing Guoying G
Journal of neurochemistry 20091117 3
Trichloroethylene, a chlorinated solvent widely used as a degreasing agent, is a common environmental contaminant. Emerging evidence suggests that chronic exposure to trichloroethylene may contribute to the development of Parkinson's disease. The purpose of this study was to determine if selective loss of nigrostriatal dopaminergic neurons could be reproduced by systemic exposure of adult Fisher 344 rats to trichloroethylene. In our experiments, oral administration of trichloroethylene induced a ...[more]