Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Rattus strain:Fisher 344

ABSTRACT: Transcriptome Profiling of Rat Liver exposed to Hexabromocyclododecane (HBCD)

PROVIDER: PRJNA395549 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR5890370.fastq.gz	Fastqsanger.gz
	SRR5890380.fastq.gz	Fastqsanger.gz
	SRR5890390.fastq.gz	Fastqsanger.gz
	SRR5890400.fastq.gz	Fastqsanger.gz
	SRR5890410.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 80

Similar Datasets

Hepatic transcriptomic alterations for 1,3,5,7,9,11-hexabromocyclododecane (HBCD) after 5-day exposure in rats

Project description:To identify liver transcripts differentially expressed due to treatment with 1,3,5,7,9,11-hexabromocyclododecane (HBCD), we collected RNA from male Harlan Sprague Dawley rats exposed to 0, 0.06, 0.641, 6.41, 64.1 or 641 mg/kg HBCD, 5 days after exposure for animals 7 weeks of age. These samples were interrogated with the Affymetrix Rat Genome 230 2.0 GeneChip array. A total of 1,2,1,23, and 247 gene transcripts were differentially expressed due to HBCD treatment after exposure to 0.06, 0.641, 6.41, 64.1 or 641 mg/kg HBCD (false discovery rate (FDR) < 0.05).

2020-07-15 | GSE153357 | GEO

Trichloroethylene induces dopaminergic neurodegeneration in Fisher 344 rats.

Project description:Trichloroethylene, a chlorinated solvent widely used as a degreasing agent, is a common environmental contaminant. Emerging evidence suggests that chronic exposure to trichloroethylene may contribute to the development of Parkinson's disease. The purpose of this study was to determine if selective loss of nigrostriatal dopaminergic neurons could be reproduced by systemic exposure of adult Fisher 344 rats to trichloroethylene. In our experiments, oral administration of trichloroethylene induced a significant loss of dopaminergic neurons in the substantia nigra pars compacta in a dose-dependent manner, whereas the number of both cholinergic and GABAergic neurons were not decreased in the striatum. There was a robust decline in striatal levels of 3, 4-dihydroxyphenylacetic acid without a significant depletion of striatal dopamine. Rats treated with trichloroethylene showed defects in rotarod behavior test. We also found a significantly reduced mitochondrial complex I activity with elevated oxidative stress markers and activated microglia in the nigral area. In addition, we observed intracellular alpha-synuclein accumulation in the dorsal motor nucleus of the vagus nerve, with some in nigral neurons, but little in neurons of cerebral cortex. Overall, our animal model exhibits some important features of Parkinsonism, and further supports that trichloroethylene may be an environmental risk factors for Parkinson's disease.

| S-EPMC3535262 | biostudies-literature

Persistence of furan-induced epigenetic aberrations in the livers of Fisher 344 rats

Project description:Furan is a heterocyclic organic compound produced in the chemical manufacturing industry and also found in a broad range of food products, including infant formulas and baby foods. Previous reports have indicated that the adverse biological effects of furan, including its liver tumorigenicity, may be associated with epigenetic abnormalities. In the present study we investigated the persistence of epigenetic alterations in rat liver. Male Fisher 344 (F344) rats were treated by gavage 5 days per week with 8 mg furan/kg body weight (bw)/day for 90 days. After the last treatment, rats were divided randomly into four groups; one group of rats was sacrificed 24 hours after the last treatment, while other groups were maintained without further furan treatment for an additional 90, 180, or 360 days. Treatment with furan for 90 days resulted in alterations in histone lysine methylation and acetylation, oxidative damage to DNA, and changes in the gene expression in the livers. A majority of these furan-induced molecular changes was transient and disappeared after the cessation of furan treatment. In contrast, histone H3 lysine 9, H3 lysine 27, and H3 lysine 56 showed a sustained and time-depended decrease in acetylation, which was associated with formation of heterochromatin and altered gene expression. These results indicate that furan-induced adverse effects may be mechanistically related to sustained changes in histone lysine acetylation that compromise the ability of cells to maintain and control properly the expression of genetic information.

2014-12-02 | GSE63740 | GEO

Rattus norvegicus strain:Fischer 344 | breed:DuCrl

Project description:RNA-Sequencing of the Thyroid and Liver of Males Rats Exposed to Acrylamide

| PRJNA326428 | ENA

Rattus norvegicus

Project description:Gene expression profiling in the rat liver exposed to diheptyl phthalate. CIBEX accession: CBX246

| PRJDB14061 | ENA

Rattus strain:Fischer 344

Project description:Age-associated genes that identify senescent cells in the liver of aged mice using single-cell RNA sequencing

| PRJDB12865 | ENA

Rattus norvegicus strain:Fisher

Project description:Rattus norvegicus strain:Fisher Transcriptome or Gene expression

| PRJNA308945 | ENA

Rattus norvegicus strain:Fisher

Project description:Rattus norvegicus strain:Fisher Transcriptome or Gene expression

| PRJNA308948 | ENA

Rattus norvegicus strain:Fisher

Project description:Rattus norvegicus strain:Fisher Transcriptome or Gene expression

| PRJNA308953 | ENA

Rattus norvegicus strain:Fisher

Project description:Rattus norvegicus strain:Fisher Transcriptome or Gene expression

| PRJNA308955 | ENA

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data