Ontology highlight
ABSTRACT:
SUBMITTER: Arana ME
PROVIDER: S-EPMC3535280 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Arana Mercedes E ME Kerns Robnet T RT Wharey Laura L Gerrish Kevin E KE Bushel Pierre R PR Kunkel Thomas A TA
DNA repair 20121015 12
We report here the transcriptional responses in Saccharomyces cerevisiae to deletion of the RNH201 gene encoding the catalytic subunit of RNase H2. Deleting RNH201 alters RNA expression of 349 genes by ≥1.5-fold (q-value <0.01), of which 123 are upregulated and 226 are downregulated. Differentially expressed genes (DEGs) include those involved in stress responses and genome maintenance, consistent with a role for RNase H2 in removing ribonucleotides incorporated into DNA during replication. Upre ...[more]