Ontology highlight
ABSTRACT:
SUBMITTER: Allen-Soltero S
PROVIDER: S-EPMC3993591 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Allen Stephanie S Martinez Sandra L SL Putnam Christopher D CD Kolodner Richard D RD
Molecular and cellular biology 20140218 8
Errors during DNA replication are one likely cause of gross chromosomal rearrangements (GCRs). Here, we analyze the role of RNase H2, which functions to process Okazaki fragments, degrade transcription intermediates, and repair misincorporated ribonucleotides, in preventing genome instability. The results demonstrate that rnh203 mutations result in a weak mutator phenotype and cause growth defects and synergistic increases in GCR rates when combined with mutations affecting other DNA metabolism ...[more]