Ontology highlight
ABSTRACT:
SUBMITTER: Marissal T
PROVIDER: S-EPMC3535425 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Marissal Thomas T Bonifazi Paolo P Picardo Michel Aimé MA Nardou Romain R Petit Ludovic Franck LF Baude Agnès A Fishell Gordon James GJ Ben-Ari Yehezkel Y Cossart Rosa R
Nature communications 20120101
The developing CA3 hippocampus is comprised by highly connected hub neurons that are particularly effective in achieving network synchronization. Functional hub neurons were shown to be exclusively GABAergic, suggesting that the contribution of glutamatergic neurons to physiological synchronization processes at early postnatal stages is minimal. However, without fast GABAergic transmission, a different situation may prevail. In the adult CA3, blocking fast GABAergic transmission induces the gene ...[more]